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Barbara A. Innes on Muck Rack

Barbara A. Innes

As seen in: Nature, Reproductive BioMedicine Online
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Articles

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By Sourima Biswas Shivhare, Guangzhou Women, Qinsheng Lu, Judith N Bulmer, Dharani K Hapangama, Qinsheng Lu, Dingqian Sun, Huomei Hou, Barbara A. Innes, G.E. Lash
| Reproductive BioMedicine Online Verified
Abstract Research question Abnormal uterine bleeding (AUB) affects approximately 30% reproductive age women. The underlying causes of AUB have been classified by the PALM-COEIN system, whereby AUB-E refers to a primary endometrial cause. AUB-E is associated with a failure in blood vessel maturation in the mid-late secretory phase endometrium. Platelet derived growth factor (PDGF)-BB is a well-known angiogenic growth factor involved in pericyte recruitment to developing vessels.
Open in Who Shared Issue with article?

Single-cell reconstruction of the early maternal–fetal interface in humans

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By Roser Vento-Tormo, Mirjana Efremova, Rachel A. Botting, Margherita Y. Turco, Miquel Vento-Tormo, Kerstin B Meyer, Jong-Eun Park, Emily Stephenson, Krzysztof Polanski, Angela Goncalves, Lucy Gardner, Staffan Holmqvist, Johan Henriksson, Angela E. Zou, Andrew Sharkey, Ben Millar, Barbara A. Innes, Laura Wood, Anna Wilbrey-Clark, Rebecca Payne, Martin A. Ivarsson, Andrew Filby, David H. Rowitch, Judith N Bulmer, Gavin J. Wright, Muzlifah Haniffa, Ashley Moffett, Sarah A Teichmann, Steve Lisgo, Michael J. T. Stubbington
| Nature Verified
Abstract During early human pregnancy the uterine mucosa transforms into the decidua, into which the fetal placenta implants and where placental trophoblast cells intermingle and communicate with maternal cells. Trophoblast–decidual interactions underlie common diseases of pregnancy, including pre-eclampsia and stillbirth. Here we profile the transcriptomes of about 70,000 single cells from first-trimester placentas with matched maternal blood and decidual cells.
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