Barbara B. Barton

1 Introduction Loneliness constitutes a multifaceted and aversive psychological state that arises from a perceived discrepancy between an individual's desired level of interpersonal connection and the actual quality or quantity of their social relationships [1]. Loneliness and social isolation overlap only to a limited extent [2, 3], indicating that loneliness represents a distinct and predominantly subjective experience.

Significant outcomes It is possible to predict patients taking medication associated with PIWG that are at risk of gaining ≥5% of body weight during the period of 4 weeks. The machine learning (ML) models became more accurate, when eating behavior, blood glucose alongside other laboratory values, and waist circumference were considered. Research needs to focus more on modifiable risk factors for PIWG to establish and implement preventive programs for patients.

Citation: Simon MS, Barton BB, Glocker C, Musil R (2022) A comprehensive approach to predicting weight gain and therapy response in psychopharmacologically treated major depressed patients: A cohort study protocol. PLoS ONE 17(7): e0271793. https://doi.org/10.1371/journal.pone.0271793 Editor: Carla Pegoraro, PLOS, UNITED KINGDOM Received: August 12, 2021; Accepted: July 7, 2022; Published: July 21, 2022 Copyright: © 2022 Simon et al.