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Bárbara Bahls on Muck Rack

Bárbara Bahls

As seen in: Wiley Online Library, MDPI
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Articles

Exploiting the 5‐amino‐11H‐indolo[3,2‐c]isoquinoline Core to Achieve Better G‐quadruplex Ligands for Cancer Therapy

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By Bárbara Bahls, Noélia Duarte, Eduarda Mendes, Ermelinda Maçôas
| Wiley Online Library Verified
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
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G-Quadruplexes in c-MYC Promoter as Targets for Cancer Therapy

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By Eduarda Mendes, Bárbara Bahls, Israa M. Aljnadi, Rita Emídio
| MDPI
Abstract : Cancer is a societal burden demanding innovative approaches. A major problem with the conventional chemotherapeutic agents is their strong toxicity and other side effects due to their poor selectivity. Uncontrolled proliferation of cancer cells is due to mutations, deletions, or amplifications in genes (oncogenes) encoding for proteins that regulate cell growth and division, such as transcription factors, for example, c-MYC.
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