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Median regression spline modeling of longitudinal FEV1 measurements in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) patients
Nine FEV 1 dynamic variables were identified from the splines and their predicted derivatives in individuals with CF (n = 177) and COPD (n = 374). Three FEV 1 dynamic classes (i.e. stable, intermediate and hypervariable) were generated and described using these variables from both cohorts.
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