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Barbara Ben Yamin on Muck Rack

Barbara Ben Yamin

As seen in: Nature
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TASP1-mediated cleavage of REV3L enhances the activity of DNA polymerase ζ in mammalian cells

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By Jordane Goulas, Caroline Pouvelle, Andrey Yurchenko, Emmanuelle Despras, Luciana de Oliveira, Pierre LaPlante, Damien Plassard, Wei Yang, Francois-Xavier Theillet, Xavier Veaute, Richard Wood, Sergey A. Nikolaev, Patricia L. Kannouche, Basile Guignier, Barbara Ben Yamin, Dorian Bochaton, Agnès M. Cordonnier
| Nature Verified
Abstract DNA polymerase ζ (Polζ) is essential for replication across damaged DNA, yet the mechanisms governing its regulation in mammalian cells remain incompletely understood. The catalytic subunit REV3L is nearly twice the size of its yeast counterpart owing to a large vertebrate-specific insertion, and recent studies reported that REV3L undergoes proteolytic cleavage by the endopeptidase TASP1.
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