Barbara Bernardim

Diazo-containing natural products have been shown to exhibit antitumor and antimicrobial activities at nanomolar–picomolar concentrations, which makes diazo compounds valuable from a biological perspective.(1,2) Already, diazo compounds have been used to investigate mechanisms of DNA cleavage in vitro,(3,4) in which the diazo moiety is likely the active pharmacophore directly involved in the damage pathway.(5,6) Some natural diazo-amino acids isolated from Streptomyces cultures have also...

1. Chudasama, V., Maruani, A. & Caddick, S. Recent advances in the construction of antibody–drug conjugates. Nat. Chem. 8, 114–119 (2016). 2. Xue, L., Karpenko, I. A., Hiblot, J. & Johnsson, K. Imaging and manipulating proteins in live cells through covalent labeling. Nat. Chem. Biol. 11, 917–923 (2015). 3. Rodrigues, T. & Bernardes, G. J. L. The missing link. Nat. Chem. 8, 1088–1090 (2016). 4. Krall, N., da Cruz, F. P., Boutureira, O. & Bernardes, G. J. L.