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Barbara Bigazzi on Muck Rack

Barbara Bigazzi

As seen in: Frontiers
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Frontiers | Hyaluronic acid and chondroitin sulfate in the management of Bacillus Calmette-Guérin-induced cystitis: what we have learned and what is still missing?

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By Marilena Gubbiotti, Emanuele Rubilotta, Stefano Rosadi, Valentina Giommoni, Barbara Bigazzi
| Frontiers
Introduction Intravesical Bacillus Calmette–Guérin (BCG) administration is a standardized and widely accepted treatment for high-risk non-muscle-invasive bladder cancer (NMIBC) (1). Despite its well-established oncological efficacy, BCG instillations may induce significant local toxicity, mainly due to damage to the glycosaminoglycan (GAG) layer, which plays a crucial role in maintaining urothelial impermeability against urinary irritants (2).
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