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Barbara Borer

As seen in: American Society for Microbiology (ASM)
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Articles

Rifabutin Is Inactivated by Mycobacterium abscessus Arr

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By Daniel Schäfle, Petra Selchow, Barbara Borer, Michael Meuli
| American Society for Microbiology (ASM)
Mechanisms of Resistance Daniel Schäfle, Petra Selchow, Barbara Borer, Michael Meuli, Anna Rominski, Bettina Schulthess, Peter Sander DOI: 10.1128/AAC.02215-20 ABSTRACT Mycobacterium abscessus exhibits Arr (ADP-ribosyltransferase)-dependent rifampin resistance. In apparent contrast, rifabutin (RBT) has demonstrated promising activity in M. abscessus infection models, implying that RBT might not be inactivated by Arr. RBT susceptibility testing of M. abscessus Δarr revealed a strongly decreased MIC.
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