Barbara Borroni
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Assessment of neurotransmitter-related structural brain changes in borderline personality disorder: an MRI study
Abstract Borderline personality disorder (BPD) is characterized by grey matter (GM) alterations in areas related to emotion regulation, impulsivity and metacognitive abilities. Dysfunction of specific neurotransmitters, including serotoninergic and dopaminergic systems, is thought to be involved, but evidence is currently limited.
Protective TMEM106B-rs3173615 delays age at onset in GRN mutation carriers
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Abstract One of the major causative genes involved in Frontotemporal dementia (FTD) is Granulin (GRN), encoding for Progranulin (PGRN). GRN mutation carriers show a substantial heterogeneity with high variability in age at onset and pathological presentation, even within the same family or identical mutations, suggesting the presence of additional genetic factors.
By Lorenzo Pagano, Claudia Saraceno, Andrea Geviti, Valentina Laganà, Giulia Giacomucci, Maria Cotelli, Assunta Ingannato, Silvia Bagnoli, Antonio Longobardi, Sonia Bellini, Ersilia Paparazzo, Alberto Montesanto, Benedetta Nacmias, Raffaele Maletta, Barbara Borroni, Roberta Ghidoni, Silvia Fostinelli, Alessandro Facconi, Alice Russotto, Davide Lagrotteria, Giuliano Binetti
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Nature
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A minimally invasive dried blood spot biomarker test for the detection of Alzheimer’s disease pathology - Nature Medicine
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Abstract Blood biomarkers have emerged as accurate tools for detecting Alzheimer’s disease (AD) pathology, offering a minimally invasive alternative to traditional diagnostic methods such as imaging and cerebrospinal fluid (CSF) analysis. Yet, the logistics surrounding venipuncture for blood collection, although considerably simpler than the acquisition of imaging and CSF, require precise processing and storage specific to AD biomarkers that are still guided by medical personnel.
By Hanna Huber, Laia Montoliu-Gaya, Wagner S. Brum, Mercè Boada, Agustín Ruiz, Anna C. Dittrich, Clive Ballard, Frederikke Kragh Clemmensen, Sebastian Palmqvist, Alberto Lleó, Daniel Alcolea, Laura Videla Toro, Anja Hviid Simonsen, Juan Fortea, Lee A. Honigberg, Barbara Borroni, Oskar Hansson, Kaj Blennow, Henrik Zetterberg
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Nature
Verified
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