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Barbara Breznik

As seen in: Frontiers, BioRxiv
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Articles

Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors

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By Tara Bayat, Barbara Breznik, Anna Lee, Sima Tozandehjani
| BioRxiv
Abstract Background: Medulloblastoma (MB) is the most malignant childhood brain cancer. Group 3 MB subtype accounts for about 25% of MB diagnoses and is associated with the most unfavorable outcomes. Herein, we report that more than half of group 3 MB tumors express melanoma antigens (MAGEs), which are potential prognostic and therapeutic markers.
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Frontiers | Development and validation of an immune infiltration/tumor proliferation-related Notch3 nomogram for predicting survival in patients with primary glioblastoma

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By Xinzhong Li, Barbara Breznik, Birbal Prasad
| Frontiers
Zong-Qing Zheng1†, Guo-Guo Zhang1†, Gui-Qiang Yuan2, Jia-Hui Hao1, Qian-Qian Nie3, Ming-Cheng Zheng4 and Zhong Wang1* 1Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China 2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China 3Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China 4Department of Neurosurgery, The Fifth Hospital of Xiamen, Xiamen, Fujian,...
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2D and 3D in vitro assays to quantify the invasive behavior of glioblastoma stem cells in response to SDF-1α

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By Barbara Breznik, Tamara Lah, Remco J. Molenaar, Vashendriya VV Hira
| future-science.com
Invasive behavior is a hallmark of cancer and a major reason why the disease is hard to eradicate, causing poor patient prognosis [1–3]. Invasive cancer cells migrate through the extracellular matrix (ECM), enabled by the secretion of proteases to degrade the ECM and alterations in the cytoskeleton [4–6]. Multiple in vitro assays and models are available to study cellular migration and invasion, such as the scratch assay, 3D bioscaffolds and microfluidic co-cultures [3,7–11].
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