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Biophysical Dissection of Isolated GPCRs: The Adenosine A2A Receptor under the Bistouries
1. Foreword: Biophysical Approaches to Answer Which Questions? During the last two to three decades, as researchers in the GPCR area, we saw a profound evolution in the study of these membrane-bound proteins. It started with the description of whole genomes and the systematic comparison of sequences that revealed the remarkable conserved topology of this exceptionally large family of proteins.
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