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Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance

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By Jing-wen Lin, Roberta Spaccapelo, Evelin Schwarzer, Mohammed Sajid, Takeshi Annoura, Katrien Deroost, Raimond B. G. Ravelli, Elena Aime, Barbara Capuccini, Anna M. Mommaas-Kienhuis, Tom O’Toole, Frans Prins, Blandine M. D. Franke-Fayard, Jai Ramesar, Séverine Chevalley-Maurel, Hans Kroeze, Abraham J. Koster, Hans J. Tanke, Andrea Crisanti, Jean Langhorne, Paolo Arese, Chris J. Janse
| jem.rupress.org
Most studies on malaria-parasite digestion of hemoglobin (Hb) have been performed using P. falciparum maintained in mature erythrocytes, in vitro. In this study, we examine Plasmodium Hb degradation in vivo in mice, using the parasite P. berghei, and show that it is possible to create mutant parasites lacking enzymes involved in the initial steps of Hb proteolysis. These mutants only complete development in reticulocytes and mature into both schizonts and gametocytes.
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