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Barbara Czako on Muck Rack

Barbara Czako

As seen in: ACS Publications, The Harvard Crimson
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Articles

Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib

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By Bypass mechanisms, Yuting Sun, Brooke A. Meyers, Barbara Czako
| cancerres.aacrjournals.org
Translational Science Yuting Sun, Brooke A. Meyers, Barbara Czako, Paul Leonard, Faika Mseeh, Angela L. Harris, Qi Wu, Sarah Johnson, Connor A. Parker, Jason B. Cross, Maria Emilia Di Francesco, Benjamin J. Bivona, Christopher A. Bristow, Jason P. Burke, Caroline C. Carrillo, Christopher L. Carroll, Qing Chang, Ningping Feng, Guang Gao, Sonal Gera, Virginia Giuliani, Justin K. Huang, Yongying Jiang, Zhijun Kang, Jeffrey J. Kovacs, Chiu-Yi Liu, Anastasia M. Lopez, Xiaoyan Ma, Pijus K.
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Allosteric SHP2 inhibitor IACS-13909 overcomes EGFR-dependent and EGFR-independent resistance mechanisms towards osimertinib

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By Yuting Sun, Brooke A. Meyers, Barbara Czako, Paul Leonard
| cancerres.aacrjournals.org
Research Article Yuting Sun, Brooke A. Meyers, Barbara Czako, Paul Leonard, Faika Mseeh, Angela L. Harris, Qi Wu, Sarah Johnson, Connor A. Parker, Jason B. Cross, Maria Emilia Di Francesco, Benjamin J. Bivona, Christopher A. Bristow, Jason P. Burke, Caroline C. Carrillo, Christopher L. Carroll, Qing Chang, Ningping Feng, Guang Gao, Sonal Gera, Virginia Giuliani, Justin K. Huang, Yongying Jiang, Zhijun Kang, Jeffrey J. Kovacs, Chiu-Yi Liu, Anastasia M. Lopez, Xiaoyan Ma, Pijus K.
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Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R

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By Barbara Czako, Jason Burke, Pijus Mandal, Joseph. R. Marszalek
| ACS Publications
Tumor-associated macrophages (TAMs) have a significant presence in the tumor stroma across multiple human malignancies and are believed to be beneficial to tumor growth. Targeting CSF1R has been proposed as a potential therapy to reduce TAMs, especially the protumor, immune-suppressive M2 TAMs. Additionally, the high expression of CSF1R on tumor cells has been associated with poor survival in certain cancers, suggesting tumor dependency and therefore a potential therapeutic target.
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