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Barbara De Marino on Muck Rack

Barbara De Marino

As seen in: Nature
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Polymeric alpha-1 antitrypsin perturbs Paneth cell proteostasis and exacerbates intestinal inflammation

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By Francesco Annunziata, JIng Lu, Claudia D’Agostino, Bruno Maria Custode, Gaetano Raiola, Rossella De Cegli, Eugenio Del Prete, Elena Polishchuk, Debora Compare, Gerardo Nardone, Francesco Neri, Nunzia Pastore, Irene Relvini, Giovanna Federico, Valentina Schiano, Veronica Maffia, Barbara De Marino, Carmen Ambrosio
| Nature Verified
Abstract Alpha-1 antitrypsin (AAT) is a serine protease inhibitor that protects tissue from neutrophil elastase and other proteases, particularly in the lung. Mutations in SERPINA1, including the Z mutation, lead to AAT deficiency (AATD), characterized by reduced circulating AAT and increased risk of pulmonary emphysema, liver cirrhosis, and hepatocellular carcinoma.
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