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Barbara E. F. Pregler on Muck Rack

Barbara E. F. Pregler

As seen in: Nature
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Articles

Core2Edge : a human glioblastoma organoid–brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion

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By Ahmad Melhem, Barbara E. F. Pregler, Juan Eduardo Rodriguez-Gatica, Lea L. Friker, Jake Thomas Verified, Marieta Toma, Mike-Andrew Westhoff, Vidhya Ravi, Valeri Borger, Dieter Henrik Heiland, Julian P. Layer, Andreas Schlitzer, Torsten Pietsch, Michael Hölzel, Andreas Waha, Hartmut Vatter, Martin Schwarz Verified, Ulrich Herrlinger, Ulrich Kubitscheck, Anna-Laura Potthoff, Matthias Schneider
| Nature Verified
Abstract Glioblastomas function as intricate cellular networks that extend into the surrounding brain tissue, facilitating long-distance communication. This malignant connectivity spans from the tumor core to remote infiltration zones, in support of the concept of glioblastoma as a whole-brain disease.
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L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial

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By Frank A. Giordano, Julian P. Layer, Roberta Turiello, Lea L. Friker, Oriol Mirallas, Anna-Laura Potthoff, Thomas Zeyen, Johannes Weller, Elena Sperk, Katharina Sahm, Christoph Oster, Sied Kebir, Niklas Schäfer, Sebastian Kadzik, Mirjam Renovanz, Torsten Pietsch, Sotirios Bisdas, Juan Manuel Sepúlveda-Sánchez, Diego Gómez-Puerto, Maria Vieito, Michael Platten, Eleni Gkika, Oliver M. Grauer, Ghazaleh Tabatabai, Matthias Schneider, Martin Glas Verified, Clemens Seidel, Ulrich Herrlinger, Michael Hölzel, Barbara E. F. Pregler, Peter Hambsch
| Nature Verified
Abstract Rapid vascular recovery is a key feature preceding glioblastoma (GBM) recurrence after radiotherapy (RT). We performed spatial expression analyses, providing a rationale for dual inhibition of two non-redundant, spatially distinct acting factors, CXCL12 and VEGF.
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