Barbara Enrich

Keywords inflammatory bowel diseases IBD Crohn’s disease CD Western diet intestinal inflammation retinoid X receptor alpha RXRa Paneth cell metabolic inflammation Introduction Crohn’s disease (CD) is a chronic remitting inflammatory condition affecting the gastrointestinal tract in more than 7 million people worldwide, and it is suspected that immunometabolism acts as an important disease mechanism in patients with CD.1,2,3 Immunometabolism of innate and adaptive immune cells describes a...

CXCR1 and CXCR2 are G protein-coupled receptors (GPCRs). 20 GPCRs consist of seven transmembrane domains joined by three intracellular loops and a C-terminal domain (referred to as i1-i4) that are important for interaction with and activation of G proteins involved in signal transduction. 21 ‘Pepducins’ are short peptides coupled to a lipid moiety that can be designed as agonists or antagonists with precise specificity in vitro and in vivo for a given GPCR.

Objective Alcoholic steatohepatitis is a life-threatening condition with short-term mortality up to 40%. It features hepatic neutrophil infiltration and blood neutrophilia, and may evolve from ethanol-induced breakdown of the enteric barrier and consequent bacteraemia. Signalling through CXCR1/2 G-protein-coupled-receptors (GPCRs), the interleukin (IL)-8 receptors, is critical for the recruitment and activation of neutrophils.