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Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites Click to copy article link Article link copied!

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By Fiona Bellany, Peter Campbell, Barbara Forte
| dx.doi.org
Introduction Click to copy section linkSection link copied! Malaria is a devastating infection that affected 263 million people worldwide and led to 610,000 deaths in 2024. (1) It is caused by protozoan Plasmodium parasites transmitted by Anopheles mosquitoes. Five species of Plasmodium parasites cause human disease: P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi. Of these, P. falciparum is associated with most deaths, although infections due to P. vivax and P.
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