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Articles

Aberrant insulin receptor expression is associated with insulin resistance and skeletal muscle atrophy in myotonic dystrophies

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By Laura Valentina Renna, Francesca Bosè, Barbara Fossati, Elisa Brigonzi
| PLOS
Loading metrics Open Access Peer-reviewed Research Article Laura Valentina Renna, Francesca Bosè, Elisa Brigonzi, Barbara Fossati, Giovanni Meola , Rosanna Cardani Laura Valentina Renna, Francesca Bosè, Elisa Brigonzi, Barbara Fossati, Giovanni Meola, Rosanna Cardani Published: March 22, 2019 https://doi.org/10.1371/journal.pone.0214254 Figures Abstract Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are autosomal dominant multisystemic disorders linked to two different genetic loci and...
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Receptor and post-receptor abnormalities contribute to insulin resistance in myotonic dystrophy type 1 and type 2 skeletal muscle

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By Laura Valentina Renna, Francesca Bosè, Sara Iachettini, Barbara Fossati
| PLOS
Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are autosomal dominant multisystemic disorders caused by expansion of microsatellite repeats. In both forms, the mutant transcripts accumulate in nuclear foci altering the function of alternative splicing regulators which are necessary for the physiological mRNA processing.
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