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Barbara Gales

As seen in: MDPI
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Articles

Sclerostin and Wnt Signaling in Idiopathic Juvenile Osteoporosis Using High-Resolution Confocal Microscopy for Three-Dimensional Analyses

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By Renata C. Pereira, Kathleen Noche, Barbara Gales, Zhangying Jennie Chen
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Sclerostin, Osteocytes, and Wnt Signaling in Pediatric Renal Osteodystrophy

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By Marciana Laster, Renata C. Pereira, Kathleen Noche, Barbara Gales
| MDPI
1. Introduction Renal osteodystrophy (ROD) is a complex disorder of bone and mineral metabolism that affects virtually all pediatric patients with CKD. ROD is associated with adverse clinical outcomes that include bone loss, skeletal deformities, abnormal bone mineralization, and an increased risk of fractures and cardiovascular events [1]. These adverse effects have long-lasting consequences that persist into adulthood and contribute to the markedly reduced life expectancy of children with CKD.
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