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Pomalidomide Plus Low-Dose Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma and Renal Impairment: Results From a Phase II Trial

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By Meletios A. Dimopoulos, Katja Weisel, Karthik Ramasamy, Barbara Gamberi
| ascopubs.org
MM-013, a noncomparative, European phase II trial, enrolled three patient cohorts: moderate RI (cohort A; estimated glomerular filtration rate, 30 to < 45 mL/min/1.73 m 2 ); severe RI (cohort B; estimated glomerular filtration rate, < 30 mL/min/1.73 m 2 ); and severe RI that requires hemodialysis (cohort C). Patients received pomalidomide 4 mg/d on days 1 to 21 and LoDEX 20 or 40 mg once per week in 28-day cycles. The primary end point was overall response rate.
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