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Barbara Gianesin on Muck Rack

Barbara Gianesin

As seen in: Wiley Online Library, MDPI, The Lancet, Blood
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Articles

Real-world evidence supports the safety and efficacy profile of luspatercept in clinically complex and heavily iron-overloaded patients

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By Barbara Gianesin, Antonietta Zappu, Giovanni Battista Ferrero
| Wiley Online Library Verified
To the Editor, Luspatercept has been demonstrated to effectively reduce transfusion requirements in adult patients with transfusion-dependent β-thalassaemia (TDT), as shown in the phase 3 BELIEVE trial and its extension study.1, 2 Following several heterogeneous and generally small real-world reports,3-6 a recent multicentre Italian study involving 231 TDT patients—the largest cohort reported to date—has further confirmed the efficacy of luspatercept in everyday clinical care.7 Moreover, that...
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Luspatercept for Transfusion‐Dependent Beta‐Thalassemia: Real‐World Experience in a Large Cohort of Patients From Italy

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By Raffaella Origa, Barbara Gianesin, Antonietta Zappu, Anna Rita Denotti
| Wiley Online Library Verified
To the Editor, The randomized, placebo-controlled phase III BELIEVE study led to the approval of luspatercept to promote erythroid maturation in the United States and Europe [1].
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Incorporating national disease burden in GBD estimates of haemoglobinopathies in Italy

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By Barbara Gianesin, Frédéric B Piel, Gian Luca Forni, IRCCS Giannina Gaslini
| The Lancet Verified
(A) Distribution according to age for patients with thalassaemia or SCD. (B) Distribution of deaths according to age for patients with thalassaemia or SCD. Error bars represent 95% CIs. GBD=Global Burden of Disease study. SCD=sickle cell disease. SITE=Società Italiana Talassemie ed Emoglobinopatie. TH=thalassaemia.
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