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Barbara Gisabella on Muck Rack

Barbara Gisabella

As seen in: Nature, Frontiers, medRxiv
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Articles

Altered molecular signaling pathways in the hippocampus of rhesus monkeys following chronic alcohol use

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By Tanya Pareek, John Vergis, Xiaolu Zhang, Donna M. Platt, Kathleen Grant, Robert E. McCullumsmith, Barbara Gisabella, Sinead M O’Donovan, Harry Pantazopoulos
| Nature Verified
Abstract Context-induced relapse is a significant factor limiting recovery from alcohol use disorder (AUD). However, the molecular processes in the hippocampus, critical for contextual memory, impacted by chronic alcohol use, remain poorly understood. We used a non-human primate model to test the hypothesis that chronic alcohol use impacts hippocampal molecular pathways that may serve as therapeutic targets for memory processing in chronic alcohol use.
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Cross-Species evidence for hippocampal CACNA1C as a therapeutic target for alcohol use disorder

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By Loc Pham, Sinead M O’Donovan, C. Austin Zamarripa, Kevin Freeman, Donna M. Platt, Kathleen Grant, Harry Pantazopoulos, Barbara Gisabella, Tanya Pareek, Obie Allen IV
| Nature Verified
Abstract Context-induced relapse is a major barrier to recovery from alcohol use disorder (AUD). Identifying molecular targets involved in contextual memories associated with alcohol use may serve as novel pharmacotherapies. Our RNAseq profiling study of the hippocampus from rhesus monkeys with chronic alcohol use identified the voltage-gated calcium channel CACNA1C as a promising therapeutic target.
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Differentially Altered Metabolic Pathways in the Amygdala of Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder

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By Xiaolu Zhang, Mahmoud A Eladawi, Barbara Gisabella, Jake Valeri
| medRxiv
The authors have declared no competing interest. This work was funded by support from the Baszucki Brain Research Foundation to HP, the NIGMS including the Molecular Center of Health and Disease (P20GM144041) to BG and MRG, and YIG-1-139-20 awarded to SMOD from the American Foundation for Suicide Prevention. The content is solely the responsibility of the authors and does not necessarily represent the official views of the American Foundation for Suicide Prevention.
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