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Barbara Izzo on Muck Rack

Barbara Izzo

As seen in: Nature
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Articles

Impact of BCR::ABL1 transcript type on RT-qPCR amplification performance and molecular response to therapy - Leukemia

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By Dolors Colomer, Barbara Izzo, Ingo Roeder, Ingmar Glauche, Thomas Ernst, Andreas Hochhaus Verified, Georg N. Franke, Jan Zuna, Lenka Hovorkova
| Nature Verified
Abstract Several studies have reported that chronic myeloid leukaemia (CML) patients expressing e14a2 BCR::ABL1 have a faster molecular response to therapy compared to patients expressing e13a2. To explore the reason for this difference we undertook a detailed technical comparison of the commonly used Europe Against Cancer (EAC) BCR::ABL1 reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) assay in European Treatment and Outcome Study (EUTOS) reference laboratories (n = 10).
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Standardization of molecular monitoring of CML: results and recommendations from the European treatment and outcome study - Leukemia

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By Francesco Albano, Dolors Colomer, Susanne Saussele, Thomas Ernst, Katerina Machova Polakova, Joana Diamond, Stéphanie Dulucq, Michal Gniot, Barbara Izzo
| Nature Verified
Abstract Standardized monitoring of BCR::ABL1 mRNA levels is essential for the management of chronic myeloid leukemia (CML) patients. From 2016 to 2021 the European Treatment and Outcome Study for CML (EUTOS) explored the use of secondary, lyophilized cell-based BCR::ABL1 reference panels traceable to the World Health Organization primary reference material to standardize and validate local laboratory tests.
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