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High Expression of NTRK1 in ETV6::RUNX1 Positive Acute Lymphoblastic Leukaemia Drives Factor Independence and Sensitivity to Larotrectinib
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The 10th Barossa meeting: Cell Signalling to Cancer Medicine - Cell Death & Disease
After a 2-year hiatus due to the COVID-19 pandemic we welcomed back the 10th Barossa meeting “Cell Signalling to Cancer Medicine” during November 2023 in the Barossa Valley, a world class wine producing area with exceptional cellar doors and local gourmet food (Fig. 1A).
Pre-B acute lymphoblastic leukaemia recurrent fusion, <i>EP300-ZNF384</i>, is associated with a distinct gene expression
Zinc-finger protein 384 (ZNF384) fusions are an emerging subtype of precursor B-cell acute lymphoblastic leukaemia (pre-B-ALL) and here we further characterised their prevalence, survival outcomes and transcriptome. Bone marrow mononuclear cells from 274 BCR-ABL1-negative pre-B-ALL patients were immunophenotyped and transcriptome molecularly characterised.
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