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RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits
RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits Barbara Jánosi, Jana F. Liewald, Marius Seidenthal, Szi-chieh Yu, Simon Umbach, Jasmina Redzovic, Dennis Rentsch, Ivan C. Alcantara, Amelie C. F. Bergs, Martin W. Schneider, Jiajie Shao, Alexander Gottschalk Journal of Neuroscience 31 July 2024, 44 (31) e0535222024; DOI: 10.1523/JNEUROSCI.0535-22.2024
RIM and RIM-binding protein localize synaptic CaV2 channels to differentially regulate transmission in neuronal circuits
Abstract At chemical synapses, voltage-gated Ca2+-channels (VGCCs) translate electrical signals into a trigger for synaptic vesicle (SV) fusion. VGCCs and the Ca2+ microdomains they elicit must be located precisely to primed SVs, to evoke rapid transmitter release. Localization is mediated by Rab3 interacting molecule (RIM) and RIM-binding proteins (RIM-BPs), which interact and bind to the C-terminus of the CaV2 VGCC α-subunit.
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