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Desflurane versus sevoflurane and postoperative inflammatory biomarkers in older adults undergoing minor- to moderate-risk noncardiac surgery
Abstract Volatile anesthetics modulate inflammatory responses, but it remains unclear whether desflurane and sevoflurane differ in their effects on postoperative inflammation. We evaluated in this secondary analysis of a prospective randomized trial, the effect of desflurane versus sevoflurane anesthesia on postoperative inflammatory biomarkers in older adults undergoing minor- to moderate-risk noncardiac surgery. We included all 190 patients who were enrolled in the main trial in this analysis.
Desflurane Versus Sevoflurane and Postoperative Cardiac Biomarkers in Older Adults Undergoing Low- To Moderate-Risk Noncardiac Surgery-Secondary Analysis of a Prospective, Observer-Blinded, Randomized Clinical Trial
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Effect of perioperative levosimendan administration on postoperative N-terminal pro-B-type natriuretic peptide concentration in patients with increased cardiovascular risk factors undergoing non-cardiac surgery: protocol for the double-blind, randomised,
adult anaesthesia heart failure clinical trials Strengths and limitations of this study This is a double-blinded prospective randomised control trial evaluating the effect of perioperative levosimendan vs placebo on postoperative N-terminal pro-brain natriuretic peptide concentrations. Elderly patients with increased cardiovascular risk factors will be included in this trial. Patients, healthcare providers and study personnel as well as outcome assessors will be blinded to randomisation.
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