Barbara Kofler

Abstract Glioblastoma (GBM) is a highly aggressive and lethal form of brain tumor that resists immunotherapy. Here we show that neuropeptide galanin (GAL) drives immunosuppression and immunotherapy resistance in GBM. Mechanistically, GBM cell-secreted GAL interacts with its receptor GALR3 on monocytic myeloid-derived suppressor cells (mMDSCs), triggering USP51-mediated deubiquitination of estrogen receptor-α, thereby engaging membrane-bound O-acyltransferase domain-containing 1 signaling.

1 Introduction Declines in avian biodiversity are often caused by invasions or unintentional introductions of bird parasites (Atkinson and LaPointe 2009), a problem that is on the rise due to the expansion of the global network of pathways (Tourchin et al. 2002; Westphal et al. 2008). In the absence of natural enemies and competitors, alien parasites can exert devastating effects on naïve host communities lacking co-evolved resistance or tolerance (Allison 1982; Fassbinder-Orth et al.

Ayuda Buscar en la ayuda Buscar en la ayuda TÉCNICA DE SPRITZ DE NIDOS PARA MITIGAR EL IMPACTO DE LA MOSCA VAMPIRO AVIAR EN LAS ISLAS GALÁPAGOS Kofler, Barbara ; Tebbich, Sabine [1] ; Cueva, Jonathan [2] ; Mauchamp-Fessl, Merlin [3] ; Schmied, Alex [3] ; Andrade, Emilia [4] ; Torres, Tatiana [4] ; Sevilla, Cristian [5] ; Causton, Charlotte [4] ; Fessl, Birgit [4] [1] Universidad de Viena, Austria.