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Barbara Laughton on Muck Rack

Barbara Laughton

As seen in: Color Research & Application, Wiley, The Lancet
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Articles

Recovery of HIV encephalopathy in perinatally infected children on antiretroviral therapy

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By Steve Innes, Barbara Laughton, Ronald Van Toorn, Kennedy N Otwombe
| Wiley
Original Article Steve Innes Corresponding Author E-mail address: innes@sun.ac.za https://orcid.org/0000-0003-3969-8680 Family Center for Research with Ubuntu (FAMCRU), Stellenbosch University, Cape Town, South Africa Department of Paediatrics and Child Health, Tygerberg Children's Hospital, Cape Town, South Africa These authors contributed equally to the manuscript.
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Should efavirenz be used in children and, if so, how?

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By Barbara Laughton, Helena Rabie, Mark F Cotton
| The Lancet Verified
1 Ford N Shubber Z Pozniak A et al. Comparative safety and neuropsychiatric adverse events associated with efavirenz use in first-line antiretroviral therapy: a systematic review and meta-analysis of randomized trials. J Acquir Immune Defic Syndr. 2015; 69 : 422-429 Furthermore, efavirenz and its major metabolite 8-hydroxy-efavirenz are toxic in neuronal cultures at concentrations observed in cerebrospinal fluid of patients.
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HIV encephalopathy with bilateral lower limb spasticity: gross motor function and antiretroviral therapy

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By Theresa N Mann, Barbara Laughton, Kirsten A Donald, Nelleke G Langerak
| Color Research & Application Verified
To describe gross motor function in children with bilateral lower limb (BLL) spasticity due to human immunodeficiency virus encephalopathy (HIVE), and to investigate the association between age, CD4 percentage, and viral load at initiation of antiretroviral therapy (ART) and current gross motor function. Thirty ambulant children with HIVE and BLL spasticity were recruited. Clinical parameters, including ART, were obtained from medical records.
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