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Inflammatory bowel disease induces inflammatory and pre-neoplastic changes in the prostate
Abstract Background Inflammatory bowel disease (IBD) has been implicated as a risk factor for prostate cancer, however, the mechanism of how IBD leads to prostate tumorigenesis is not known. Here, we investigated whether chronic intestinal inflammation leads to pro-inflammatory changes associated with tumorigenesis in the prostate.
Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation
We first examined the expression pattern of Bmi1 protein in mouse prostate tissues by immunohistochemistry, using the known pattern of Bmi1 expression in the intestinal epithelium as a positive control (Supplementary Fig. 1a). In the adult prostate, we divided the prostate gland into proximal, intermediate and distal thirds and found that most Bmi1-expressing cells localized to the proximal region of the gland (Supplementary Fig. 1b–g).
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