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Therapeutic Potential of 2,2′:6′,2″-Terpyridine-Based Au(III), Pt(II), and Mn(II) Complexes against 2D and 3D Human Colorectal Resistant Cancer Cells
Abstract Click to copy section linkSection link copied! The antiproliferative effect of [AuCl(tmp-terpy)](PF6)2 (1), [PtCl(tmp-terpy)](CF3SO3) (2), [MnCl2(tmp-terpy)] (3), and 4′-(3,4,5-trimethoxy-phenyl)-2,2′:6′,2″-terpyridine (tmp-terpy) was analyzed in sensitive and doxorubicin-resistant (DoxR) colorectal cancer (CRC) cell lines and in normal primary human fibroblasts.
Optimization of Antiproliferative Properties of Triimine Copper(II) Complexes
Introduction Click to copy section linkSection link copied! Cancer ranks second as the leading cause of death worldwide, behind cardiovascular diseases. Regarding global trends, however, there is a high probability that this statistical tendency will be reversed before 2030. Besides surgery, the main treatment of cancer is based on chemotherapy.
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