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Barbara Manfredi on Muck Rack

Barbara Manfredi

As seen in: Taylor & Francis Online, Journal of Pharmacology and Experimental Therapeutics, International Journal of Medical Sciences
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Articles

Full article: Use of a conditional Glanzmann thrombasthenia mouse model reveals a supportive and possibly non-adhesive role for TLT-1 in the platelet-fibrinogen interaction

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By Siobhan Branfield, Barbara Manfredi, Nicholas Koshy, Yashieta Somani
| Taylor & Francis Online
ABSTRACT The platelet integrin receptor, αIIbβ3, binds fibrinogen to mediate platelet-platelet contacts, regulate hemostasis, and modulate inflammation. The Triggering Receptor Expressed in Myeloid (TREM) – Like (TLT)-1 is an enigmatic 34kD receptor found on platelets that affects their hemostatic and inflammatory functions. Similar to αIIbβ3, TLT-1’s ligand is also fibrinogen; however, TLT-1’s direct role in platelet function remains unknown.
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Interrogating a Compound Library in Search of an Inhibitor for TREM-like Transcript-1 to Fibrinogen Binding

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By Barbara Manfredi, Siobhan Branfield, Andrea Acsiniuc, Javier Menédez-Pérez
| Journal of Pharmacology and Experimental Therapeutics
Abstract Cardiovascular disease (CVD) remains one of leading causes of death worldwide. Aberrant platelet function mediate fibrin(ogen) rich thrombi that lead to occlusive thrombi associated with mortality. The receptor, TREM-like transcript-1 (TLT-1), stored in the platelet a-granules and released upon platelet activation, binds fibrinogen and von Willebrand factor. Once it is released from platelets TLT-1 is a potential therapeutic target to prevent the thrombosis associated with CVD.
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Nitrogen Containing Bisphosphonates Impair the Release of Bone Homeostasis Mediators and Matrix Production by Human Primary Pre-Osteoblasts

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By Stefania Niada, Giovanni Lombardi, Chiara Giannasi, Davide Farronato, Barbara Manfredi, Giampietro Farronato, Anna Teresa Brini
| International Journal of Medical Sciences Verified
PDF Int J Med Sci 2019; 16(1):23-32. doi:10.7150/ijms.27470 Research Paper Chiara Giannasi1,2, Stefania Niada2, Davide Farronato3, Giovanni Lombardi2, Barbara Manfredi1, Giampietro Farronato1,4, Anna Teresa Brini1,2 1. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. 2. IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. 3. Department of Medicine and Surgery, Insubria University, Varese, Italy. 4.
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