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Barbara Mannucci on Muck Rack

Barbara Mannucci

As seen in: Nature, MDPI
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Articles

Structural and Mechanistic Characterization of the Flavin-Dependent Monooxygenase and Oxidase Involved in Sorbicillinoid Biosynthesis

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By Gwen Tjallinks, Quoc-Thai Nguyen, Barbara Mannucci, Nicolò Angeleri
| dx.doi.org
Introduction Click to copy section linkSection link copied! Sorbicillinoids are a large family of yellow secondary metabolites produced by various distantly related ascomycetes, including Trichoderma (1) and Penicillium. (2) Sorbicillinoids are particularly notable for their complex molecular structures, which often include highly oxygenated bicyclic and tricyclic frameworks.
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Structure, mechanism, and evolution of the last step in vitamin C biosynthesis - Nature Communications

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By Barbara Mannucci, María Laura Mascotti, Marco W. Fraaije, Neelam Jamil
| Nature Verified
Abstract Photosynthetic organisms, fungi, and animals comprise distinct pathways for vitamin C biosynthesis. Besides this diversity, the final biosynthetic step consistently involves an oxidation reaction carried out by the aldonolactone oxidoreductases. Here, we study the origin and evolution of the diversified activities and substrate preferences featured by these flavoenzymes using molecular phylogeny, kinetics, mutagenesis, and crystallographic experiments.
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In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis - Nature Catalysis

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By Callum R. Nicoll, Barbara Mannucci, Federica Corana, María Laura Mascotti, Andrea Gottinger, Domiziana Cecchini
| Nature Verified
Abstract Metabolons are protein assemblies that perform a series of reactions in a metabolic pathway. However, the general importance and aptitude of metabolons for enzyme catalysis remain poorly understood. In animals, biosynthesis of coenzyme Q is currently attributed to ten different proteins, with COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9 forming the iconic COQ metabolon. Yet several reaction steps conducted by the metabolon remain enigmatic.
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