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Multikinase Treatment of Glioblastoma: Evaluating the Rationale for Regorafenib
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Glioblastoma Biology, Genetics and Possible Therapies
Glioblastoma is the most aggressive intracranial tumor. Current treatment consists of surgery, radiotherapy, and chemotherapy (temozolomide). Resistance to radiotherapy and chemotherapy are frequent. Temozolomide is preferably used in patients who do not express MGMT. Temozolomide induces the formation of O6-methylguanine in DNA. MGMT repairs this DNA damage. Therefore, glioblastoma cells become resistant to temozolomide when MGMT expression ensures the repair of damaged DNA by temozolomide.
Newest Tillman Scholars Named
Making it an even dozen at USF, three former service members are honored with highly competitive and prestigious scholarship for military veterans. Tillman Scholars (l-r) Trillitye Finlayson, David Welker and LaChiana Hamilton all plan on professions in healthcare as they continue to serve society in new ways. Photos by Aimee Blodgett | USF News Three USF students are among 59 U.S. service veterans and military spouses who were named 2014 Tillman Military Scholars. Trillitye Finlayson, LaChiana A.
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