Barbara Niederdorfer

Abstract We report a single-arm phase 2 trial of pembrolizumab in advanced malignant peripheral nerve sheath tumors at Oslo University Hospital. Long-lasting response in 1 of 8 patients was associated with high tumor density of PD-1+CD8+ T cells. Mixed response in another patient was associated with PD-L1 expression, and PD-L1 was mostly not co-expressed on CD68+ macrophages or CD8+ cells. The study was prematurely closed due to a slow accrual rate.

Abstract : Colorectal cancer (CRC) is one of the most prevalent cancers, driven by several factors including deregulations in intracellular signalling pathways. Small extracellular vesicles (sEVs) are nanosized protein-packaged particles released from cells, which are present in liquid biopsies.

Correction to: Scientific Reports https://doi.org/10.1038/s41598-020-68441-0, published online 14 July 2020 The original version of this Article contained errors in the Reference list. References 46–50 were incorrectly listed as References 44–48 and References 51–52 were incorrectly listed as References 49–50 respectively. In addition, References 44 and 45 were omitted. References 44 and 45 are listed below: Bain, J. et al. The selectivity of protein kinase inhibitors: A further update. Biochem. J.