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Barbara Niederoest on Muck Rack

Barbara Niederoest

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Articles

Mechanical gating of tendon fibrogenic transcription in systemic sclerosis

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By Amro A. Hussien, Robert J. Knell, Matthew R. Aronoff, Florian Renoux, Helma Wennemers, Oliver Distler, Jess G. Snedeker, Stefania L. Wunderli, Barbara Niederoest, Amela Hukara, Jasper Foolen
| Nature Verified
Abstract Fibrosis arises from aberrant tissue repair in systemic sclerosis and is characterized by progressive stiffening across multiple tissues, including tendons. How altered tissue mechanics sustain fibrotic remodeling remains poorly understood, in part because of limited experimental models that capture key biophysical features of fibrosis. Here we develop a modular cantilever-based mechano-culture platform that enables tendon-like constructs to be maintained under controlled static tension.
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