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Barbara Ottolini on Muck Rack

Barbara Ottolini

As seen in: Nature, Journal of Clinical Pathology, Bored Panda, BioRxiv
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Articles

Defining cat mitogenome variation and accounting for numts via multiplex amplification and Nanopore sequencing

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By Emily Patterson, Gurdeep Matharu Lall, Rita Neumann, Barbara Ottolini
| BioRxiv
New Results doi: https://doi.org/10.1101/2023.06.19.545568 Abstract Hair shed by domestic cats is a potentially useful source of forensic evidence. Analysable hair DNA is predominantly mitochondrial, but the recent domestication history of cats means that mtDNA diversity is low. A 402-bp control region segment is usually sequenced, defining only a small number of distinct mitotypes in populations.
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Mitogenome sequences of domestic cats demonstrate lineage expansions and dynamic mutation processes in a mitochondrial minisatellite

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By Emily Patterson, Rita Neumann, Barbara Ottolini, Gurdeep Matharu Lall
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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Longitudinal monitoring of circulating tumour DNA improves prognostication and relapse detection in gastroesophageal adenocarcinoma

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By Anne Thomas, Ali Mohamed, Barbara Ottolini, Mark R. Openshaw
| Nature Verified
Abstract Background Gastroesophageal adenocarcinoma (GOA) has poor clinical outcomes and lacks reliable blood markers. Here we present circulating tumour DNA (ctDNA) as an emerging biomarker. Methods Forty patients (17 palliative and 23 curative) were followed by serial plasma monitoring. Primary tumour DNA was analysed by targeted next-generation sequencing to identify somatic single-nucleotide variants (SNVs), and Nanostring nCounter® to detect copy number alterations (CNAs).
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