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Triazole derivatives inhibit the VOR complex-mediated nuclear transport of extracellular particles: Potential application in cancer and HIV-1 infection
Extracellular vesicles (EVs) appear to play an important role in intercellular communication in various physiological processes and pathological conditions such as cancer. Like enveloped viruses, EVs can transport their contents into the nucleus of recipient cells, and a new intracellular pathway has been described to explain the nuclear shuttling of EV cargoes.
Exploring the therapeutic potential of focal adhesion kinase inhibition in overcoming chemoresistance in pancreatic ductal adenocarcinoma
**Author for correspondence: E-mail Address: elisa.giovannetti@gmail.com Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center (VUmc) De Boelelaan 1117, Amsterdam, 1081HV, The Netherlands Cancer Pharmacology Lab, Fondazione Pisana per la Scienza, Via Ferruccio Giovannini 13, San Giuliano Terme, Pisa, 56017, Italy
Nortopsentins as Leads from Marine Organisms for Anticancer and Anti-Inflammatory Agent Development
2.1. Nortopsentin Derivatives as Antiproliferative Agents 2.1.1. Thiazoles Several bis-indolyl-thiazole compounds 1 (Figure 2) were synthesised and tested against the National Cancer Institute (NCI, Bethesda, MD 20892, USA) full panel of 60 human cancer cell lines derived from nine cancer cell types and grouped into disease subpanels including leukaemia, non-small cell lung, colon, central nervous system, melanoma, ovarian, renal, prostate, and breast cancers.
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