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Barbara Pees

As seen in: BioRxiv
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Articles

Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans

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By Lena Peters, Moritz Drechsler, Barbara Pees, Georgia Angelidou
| BioRxiv
Abstract Protection against pathogens is a major function of the gut microbiota. Although bacterial natural products have emerged as crucial components of host-microbiota interactions, their exact role in microbiota-mediated protection is largely unexplored. We addressed this knowledge gap with the nematode Caenorhabditis elegans and its microbiota isolate Pseudomonas fluorescens MYb115 that is known to protect against Bacillus thuringiensis (Bt) infection.
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Identification of intestinal mediators of Caenorhabditis elegans DBL-1/BMP immune signaling shaping gut microbiome composition

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By Barbara Pees, Rahul Bodkhe, Kenneth Trang, Siavash Karimzadegan
| BioRxiv
Abstract The composition of the gut microbiome is determined by a complex interplay of diet, host genetics, microbe-microbe competition, abiotic factors, and stochasticity. Previous studies have demonstrated the importance of host genetics in community assembly of the Caenorhabditis elegans gut microbiome and identified a pivotal role for DBL-1/BMP immune signaling in determining the abundance of gut Enterobacteriaceae, in particular of the genus Enterobacter.
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An Enterobacteriaceae bloom in aging animals is restrained by the gut microbiome

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By Barbara Pees, Dan Kim, Rebecca Choi, Rahul Bodkhe
| BioRxiv
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