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Barbara Pro

As seen in: The Lancet, Ash Publications
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Articles

Multicenter phase 2 study of romidepsin plus lenalidomide for previously untreated peripheral T-cell lymphoma

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By Daiichi Sankyo, Barbara Pro
| Ash Publications
Peripheral T-cell lymphoma (PLTCL) is a group of aggressive non-Hodgkin lymphomas (NHL) often associated with poor prognosis when treated with conventional chemotherapy.1 Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) is the most commonly prescribed induction treatment for systemic PTCL.2 With the exception of ALK+ anaplastic large cell lymphoma (ALCL), CHOP is historically associated with overall response rate (ORR) ranging from 60% to 80%, complete response (CR) ranging...
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Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial

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By Steven Horwitz, Owen O'Connor, Tim Illidge, Barbara Pro
| The Lancet Verified
Background Based on the encouraging activity and manageable safety profile observed in a phase 1 study, the ECHELON-2 trial was initiated to compare the efficacy and safety of brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone (A+CHP) versus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) for the treatment of CD30-positive peripheral T-cell lymphomas.
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