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Barbara R. Migeon on Muck Rack

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Embryonic loss of human females with partial trisomy 19 identifies region critical for the single active X

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By Johns Hopkins, Michael Beer, Barbara R. Migeon, Hans T. Bjornsson
| PLOS
To compensate for the sex difference in the number of X chromosomes, human females, like human males have only one active X. The other X chromosomes in cells of both sexes are silenced in utero by XIST, the Inactive X Specific Transcript gene, that is present on all X chromosomes. To investigate the means by which the human active X is protected from silencing by XIST, we updated the search for a key dosage sensitive XIST repressor using new cytogenetic data with more precise resolution.
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