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Barbara R. Sheedy on Muck Rack

Barbara R. Sheedy

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INCREASED ENDOCRINE ACTIVITY OF XENOBIOTIC CHEMICALS AS MEDIATED BY METABOLIC ACTIVATION

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By Richard C. Kolanczyk, Jeffrey Denny, Victoria Olson, Barbara R. Sheedy
| Wiley Online Library Verified
The US EPA is faced with long lists of chemicals that require hazard assessment. This research is part of a larger effort to develop in vitro assays and QSARs applicable to untested chemicals on US EPA inventories through study of estrogen receptor (ER) binding and estrogen mediated gene expression in fish. The current effort investigates metabolic activation of chemicals resulting in increased estrogenicity.
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