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Barbara Reaves on Muck Rack

Barbara Reaves

As seen in: The Journal of Immunology
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Articles

P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals

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By Payel Sil, Craig Hayes, Barbara Reaves, Patrick J Breen Verified
| The Journal of Immunology Verified
Human neutrophils (polymorphonuclear leukocytes [PMNs]) generate inflammatory responses within the joints of gout patients upon encountering monosodium urate (MSU) crystals. Neutrophil extracellular traps (NETs) are found abundantly in the synovial fluid of gout patients. The detailed mechanism of MSU crystal–induced NET formation remains unknown. Our goal was to shed light on possible roles of purinergic signaling and neutrophil migration in mediating NET formation induced by MSU crystals.
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NET formation induced by gout-associated monosodium urate crystals requires IL-8-mediated neutrophil migration and is inhibited by the P2Y6 receptor antagonist MRS2578.

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By Craig Hayes, Barbara Reaves, Balazs Rada, Payel Sil, Jeremy Sokolove
| The Journal of Immunology Verified
Human neutrophils generate inflammatory responses within the joints of gout patients upon encountering Monosodium Urate (MSU) crystals. Studies (including ours) show that neutrophil extracellular traps (NETs) are found abundantly in the synovial fluid (SF) of gout patients and are crucial for the onset of the autoinflammatory cascade. Our goal is to shed light on possible roles of purinergic signaling and neutrophil migration in mediating in vitro NET formation induced by MSU crystals.
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Petition #SaveThunderRoad

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By Jana Gibson, Barbara Reaves, Dennis Davis
| ipetitions.com
#SaveThunderRoad sign today to help us tell Carowinds to keep Thunder Road!
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