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In vitro effects of PI3K/mTOR inhibition in canine hemangiosarcoma

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By Barbara Rose, Douglas H. Thamm, Alex A. Pyuen, Travis Meuten
| PLOS
While extremely rare in humans, hemangiosarcoma (HSA) accounts for nearly 2% of canine neoplasia, and is characterized by both aggressive local growth/invasion and a high rate of metastasis. Both canine and human HSA exhibit sustained aberrant PI3K/Akt/mTOR pathway signaling. The purpose of this study was to examine the in vitro effects of a novel dual PI3K/mTOR inhibitor, VDC-597, in three canine HSA cell lines (DEN-, CIN-, and SB-HSA).
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