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T-bet+ B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms - Nature Communications
Abstract Endogenous retroviruses (ERVs) are an integral part of the mammalian genome. The role of immune control of ERVs in general is poorly defined as is their function as anti-cancer immune targets or drivers of autoimmune disease. Here, we generate mouse-strains where Moloney-Murine Leukemia Virus tagged with GFP (ERV-GFP) infected the mouse germline. This enables us to analyze the role of genetic, epigenetic and cell intrinsic restriction factors in ERV activation and control.
Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by Christin Schmidt * and Barbara S. Schnierle * Section AIDS and Newly Emerging Pathogens, Department of Virology, Paul-Ehrlich-Institut, 63225 Langen, Germany * Authors to whom correspondence should be addressed.
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