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Barbara Schmalfeldt on Muck Rack

Barbara Schmalfeldt

As seen in: Nature, BMC Cancer, Implementation Science
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Articles

Pre-operative circulating tumor cells predict worse treatment outcome in patients with high-grade serous ovarian cancer

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By Paul Rademacher, Sandra Lenz, Piet Sonnemann, Anna Jaeger, Leticia Oliveira-Ferrer, Linn Woelber, Sabine Riethdorf, Klaus Pantel, Barbara Schmalfeldt, Simon A. Joosse, Annabelle Lobermeyer, Jenna Sophie Schöllhorn, Maximilian C. Wankner, Cornelia Coith, Mina Netkova-Heintzen, Katharina Prieske
| Nature Verified
Abstract High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy. Pre- and post-operative, non-invasive biomarkers for reliable treatment outcome prediction, (minimal) residual disease detection, and prognosis are not yet established in clinical practice for these patients.
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Ovarian cancer cells regulate their mitochondrial content and high mitochondrial content is associated with a poor prognosis - BMC Cancer

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By Mariam Petrosyan, Leticia Oliveira-Ferrer, Barbara Schmalfeldt, Jil Weigelt, Catharina Bartmann, Johannes Dietl, Christine Stürken, Udo Schumacher
| BMC Cancer Verified
First, the presence or absence of immunohistochemically detectable mitochondria was validated in human kidneys and in different clinical samples of ovarian cancers using three monoclonal antibodies directed against different mitochondrial antigens, namely HSP60, fumarase and SDHA. All three antibodies detected mitochondria in the proximal tubule of the kidney and the isotype controls were negative (Fig. 1). Individual mitochondria could be identified using the HSP-60 monoclonal antibody (Fig. 2).
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Evaluation of a program for routine implementation of shared decision-making in cancer care: results of a stepped wedge cluster randomized trial - Implementation Science

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By Isabelle Scholl, Pola Hahlweg, Anja Lindig, Wiebke Frerichs, Jördis M Zill, Carsten Bokemeyer, Barbara Schmalfeldt, Isabell Witzel, Martin Härter, Levente Kriston, Hannah Cords, Anja Coym, Ralf Smeets, Tobias Vollkommer
| Implementation Science Verified
Isabelle Scholl ORCID: orcid.org/0000-0002-7639-08801 na1, Pola Hahlweg1 na1, Anja Lindig1, Wiebke Frerichs1, Jördis Zill1, Hannah Cords1, Carsten Bokemeyer2, Anja Coym2, Barbara Schmalfeldt3, Ralf Smeets4, Tobias Vollkommer4, Isabell Witzel3, Martin Härter1 na1 & Levente Kriston1 na1 Implementation Science volume 16, Article number: 106 (2021) Cite this article Abstract Background Shared decision-making (SDM) is preferred by many patients in cancer care.
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