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The Influence of Extracellular Citrate in Physiological Concentration on the Proliferation of Malignant Melanoma
1 Introduction Malignant melanoma is responsible for over 90% of skin cancer-related deaths, with tumour thickness closely correlating with aggressiveness and metastatic potential. While early-stage prognosis is favourable, treating advanced disease remains challenging. Recent therapies, such as immune checkpoint inhibitors (anti-PD-1, anti-CTLA-4) and BRAF/MEK inhibitors, have improved survival, yet novel treatment strategies are still needed [1].
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