Barbara Sennino
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Amplification of Oncolytic Vaccinia Virus Widespread Tumor Cell Killing by Sunitinib through Multiple Mechanisms
Tumor Biology and Immunology Amplification of Oncolytic Vaccinia Virus Widespread Tumor Cell Killing by Sunitinib through Multiple Mechanisms Minah Kim, Maximilian Nitschké, Barbara Sennino, Patrizia Murer, Brian J. Schriver, Alexander Bell, Aishwarya Subramanian, Corry E. McDonald, Jiahu Wang, Howard Cha, Marie-Claude Bourgeois-Daigneault, David H. Kirn, John C. Bell, Naomi De Silva, Caroline J. Breitbach and Donald M. McDonald
Amplification of oncolytic vaccinia virus widespread tumor cell killing by sunitinib through multiple mechanisms
Amplification of oncolytic vaccinia virus widespread tumor cell killing by sunitinib through multiple mechanisms Minah Kim, Maximilian Nitschké, Barbara Sennino, Patrizia Murer, Brian J. Schriver, Alexander M. Bell, Aishwarya Subramanian, Corry E. McDonald, Jiahu Wang, Howard Cha, Marie-Claude Bourgeois-Daigneault, David H. Kirn, John C. Bell, Naomi De Silva, Caroline J. Breitbach and Donald M McDonald Cancer Res December 19 2017 DOI: 10.1158/0008-5472.CAN-15-3308
PLOS ONE: Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice
Poxvirus-based active immunotherapies mediate anti-tumor efficacy by triggering broad and durable Th1 dominated T cell responses against the tumor. While monotherapy significantly delays tumor growth, it often does not lead to complete tumor regression. It was hypothesized that the induced robust infiltration of IFNγ-producing T cells into the tumor could provoke an adaptive immune evasive response by the tumor through the upregulation of PD-L1 expression.
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