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Barbara Sohr

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Cover Picture: Transforming Aryl‐Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans‐Cyclooctenes (Angew. Chem. Int. Ed. 5/2025)

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By Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr
| Wiley Online Library Verified
Andres Fernandez del Castillo Institute of Applied Synthetic Chemistry, TU Wien, 1060 Vienna, Austria Center for Systems Biology & Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 02114 Boston, MA, USA Search for more papers by this author
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Transforming Aryl‐Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans‐Cyclooctenes

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By Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr
| Wiley Online Library Verified
Introduction Bioorthogonal chemistry has revolutionized the field of chemical biology by offering unparalleled precision in initiating and controlling molecular transformations within complex biological matrices.1 Among the most impactful of these methods is the inverse electron demand Diels–Alder (IEDDA)-initiated reaction between 1,2,4,5-tetrazines (Tz) and trans-cyclooctenes (TCO, Figure 1a).2 Due to its exceptional reaction kinetics, Tz/TCO click chemistry facilitates fast and efficient...
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Transforming Aryl‐Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans‐Cyclooctenes

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By Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr
| pericles.pericles-prod.literatumonline.com
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
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