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Barbara Sottero on Muck Rack

Barbara Sottero

As seen in: MDPI
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Articles

Antioxidants | Free Full-Text | 24-Hydroxycholesterol Induces Tau Proteasome-Dependent Degradation via the SIRT1/PGC1α/Nrf2 Pathway: A Potential Mechanism to Counteract Alzheimer’s Disease

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By Gabriella Testa, Serena Gea Giannelli, Barbara Sottero, Erica Staurenghi
| MDPI
Abstract : Considerable evidence indicates that cholesterol oxidation products, named oxysterols, play a key role in several events involved in Alzheimer’s disease (AD) pathogenesis. Although the majority of oxysterols causes neuron dysfunction and degeneration, 24-hydroxycholesterol (24-OHC) has recently been thought to be neuroprotective also.
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