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Suicidal ideation in adults with opioid use disorder treated with buprenorphine-naloxone versus extended-release naltrexone
ABSTRACT Background: Depression and suicidal ideation are prevalent in patients with opioid use disorder (OUD). Objectives: This study examined changes in suicidal ideation during OUD treatment with buprenorphine-naloxone or extended-release naltrexone. Methods: 570 adults with OUD (29.6% female) were recruited into a National Drug Abuse Clinical Trials Network randomized trial (NCT02032433) comparing extended-release naltrexone versus buprenorphine-naloxone for opioid relapse prevention (X:BOT).
136. Broad Cytokine and Chemokine Involvement in Major Depressive Disorder
Interleukin (IL)-6 and tumor necrosis factor (TNF)α are reportedly elevated in major depressive disorder (MDD) and in response to acute psychosocial stress, suggesting a role of inflammation in MDD. Less is known about other potentially implicated cytokines/chemokines in the inflammatory response.
Predictors of Suicide Related Behaviors in a Sample of High-Risk Black Youth
Suicide remains a leading cause of death in youth. In recent years, suicide rates have risen disproportionately in Black youth, yet we know very little about risk factors specific to this group or the reasons behind this trend. We sought to identify the role of parental history of suicidal behavior in predicting suicide-related behaviors (SRB) in a sample of Black youth at high risk for suicidal behavior.
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